Malignant tumor of the peripheral nerve sheath in a rabbit: case report

Authors

  • Jordana de Barros Batista Universidade Federal Rural do Rio de Janeiro - UFRJ
  • Olivia Zen Gianfrancisco Universidade Federal Rural do Rio de Janeiro - UFRJ
  • Matheus Dias Cordeiro Universidade Federal Rural do Rio de Janeiro - UFRJ

DOI:

https://doi.org/10.24859/SaberDigital.2023v16n02.1423

Keywords:

schwannoma, rabbits, lionhead, Oryctolagus cuniculus, neoplasia

Abstract

Introduction: The occurrence of malignant tumors of the peripheral nerve sheath (NPMT), also known as malignant schawannoma, in rabbits (Oryctolagus cuniculus) is little described in the literature, despite this, we have some reports in other animal species such as dogs, cattle and equines. Objective: The objective of this work is to report a clinical case of a malignant tumor of the peripheral nerve sheath in a rabbit (Orytolagus cuniculus), addressing the clinical symptoms, results of tests and procedures performed during the patient's treatment. Case report: In this case report, a nine-year-old lionhead rabbit was seen at a veterinary clinic with a nodule lateral to the left forelimb. The patient underwent physical and laboratory examinations, such as blood count and aspiration cytology, in order to assess his general condition and diagnose the cellular nature of the nodule. After manipulation of the nodule for the collection of exams, the lesion presented a rapid evolution and grew to approximately 10 cm in diameter. The result of the aspiration cytology of the nodule suggested neoplasia of cells of mesenchymal origin. Given this result and the rapid growth of the nodule, the patient underwent surgery to amputate the affected limb, which was referred for histopathological analysis. The analysis result confirmed the suspicion of a malignant schwannoma. Conclusion: The present study served as an alert for the need for further studies involving this type of sarcoma, assessing incidence, new possibilities for treatment and possible prophylaxis.

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References

BRENNER, L., LAUX, J., DE OLIVEIRA DUARTE, K., DOS SANTOS, E. O., & DA COSTA ALLGAYER, M. Referências hematológicas e bioquímicas em coelhos domésticos (Oryctolagus cuniculus) da região de Canoas (RS). Veterinária e Zootecnia, v. 28, p. 1-7. 2021

CASTRO T.C., GARCIA M., CHACÓN R.D., et al. Malignant peripheral nerve sheath tumour in a rabbit: clinical and histopathological findings. J Comp Pathol. v.166, p. 70-73, 2019.

GÓMEZ, E., FERRER, L. M., SANCHIS, I., & PÉREZ, J. Schwannoma in a rabbit colony. Laboratory Animals, v. 45, n. 2, p. 150-153, . doi: 10.1258/LA.2010.010098, 2011.

KIM, S. H., KIM, S. W., KIM, J. H., & JUNG, D. I. Peripheral nerve sheath tumors in pet rabbits: four cases. Journal of Exotic Pet Medicine, v. 32, p. 49-55. doi: 10.1016/J.JEPM.2020.03.001, 2020.

CASTRO T.C., GARCIA M., CHACÓN R.D., et al. Malignant peripheral nerve sheath tumour in a rabbit: clinical and histopathological findings. J Comp Pathol. v.166, p. 70-73, 2019.

GÓMEZ, E., FERRER, L. M., SANCHIS, I., & PÉREZ, J. Schwannoma in a rabbit colony. Laboratory Animals, v. 45, n. 2, p. 150-153, 2011.

KIM, S. H., KIM, S. W., KIM, J. H., & JUNG, D. I. Peripheral nerve sheath tumors in pet rabbits: four cases. Journal of Exotic Pet Medicine, v. 32, p. 49-55, 2020.

QUESENBERRY K.E., CARPENTER J.W. Ferrets, Rabbits and Rodents Clinical Medicine and Surgery. St. Louis: Elsevier. p. 496, 2012.

MANZANO, M. A., NODA, M., MARTÍNEZ, C., CAPDESUÑER, Y., & PERERA, Y. Peripheral nerve sheath tumors in rabbits raised for production of heterologous antitoxins. Journal of Veterinary Diagnostic Investigation. v. 30, n. 5, p. 733-738, 2018.

OLIVEIRA, M.N.1 ; SOUSA, L.G.1 ; VIEIRA, M.P.2 ; ARAUJO, R.B.2 ; BOUTY, L.F.M.2 ; VIANA, D.A. Tumor maligno da bainha do nervo periférico em coelho: relato de caso. Anais Onco In Rio. Fortaleza. v. 2, p. 50-52, 2018. Disponível em:https://irpcdn.multiscreensite.com/38c5de7d/files/uploaded/ONCO%20IN%20RIO%202018%202.pdf. Acesso em: 17 fev. 2023.

RODRIGUEZ C.A. Schwannoma benigno do nervo intercostal simulando neoplasia de pulmão. Arquivos de Neuro-Psiquiatria, v.62, p.:1100-1103. 2004.

ROSSETTI, D. P., WERNECK, M. R., SILVA, R. C., MENDES, L. C. N., & COSTA, F. P. Peripheral nerve sheath tumors in horses: retrospective study of 13 cases. Pesquisa Veterinária Brasileira. v. 34, n. 3, p. 261-266, 2014.

SCHOÖNIGER, S.; HORN, L.C.; SCHOON, H. A. Tumors and Tumor-like Lesions in the Mammary Gland of 24 Pet Rabbits: A Histomorphological and Immunohistochemical Characterization. Veterinary Pathology. v.51, p.569-580, 2014.

SCHULMAN F.Y., JOHNSON T.O, FACEMIRE P.R., FANBURG-SMITH J.C. Feline peripheral nerve sheath tumors: histologic, immunohistochemical, and clinocopathologic correlation (59 tumor in 53 cats). Veterinary Patholopgy. v. 46, p. 1166–1180, 2009.

SUMMERS B.A., CUMMINGS J.F. "Peripheral Nervous System." In: Veterinary Neuropathology. St. Louis, MO: Mosby-Year Book, Inc.; p. 233-6. 1995.

TAYLOR S.M. Doenças dos Nervos Periféricos e da Junção Neuromuscular. In: Nelson R.W., Couto C.G. Medicina Interna de Pequenos Animais. V. 4, ed. Rio de Janeiro: Elsevier, p. 1094-1109, 2010.

VENNEN, K.M.; MITCHELL, M.A. Rabbits. In: Mitchell, M.A.; Tully, T.N. Manual of Exotic Pet Practice. 1.ed., St Louis: Saunders Elsevier, p.391-392, 2009.

WEISS S.W., GOLDBLUM J.R. Benign tumor of the peripheral nerves. In: Weiss S.W., Goldblum J.R. Enzinger and Weiss’s soft tissue tumors. V. 4. ed. St. Louis: Mosby, p. 1111-1208,, 2008.

WOBESER B.K., KIDNEY B.A., POWERS B.E., WITHROW S.J., MAYER M.N., SPINATO M.T. Malignant peripheral nerve sheath tumor in a rabbit. Vet Pathol., v. 38, p. 240-243, 2001.

Published

2023-08-10

How to Cite

de Barros Batista, J. ., Zen Gianfrancisco, O., & Dias Cordeiro, M. . (2023). Malignant tumor of the peripheral nerve sheath in a rabbit: case report. Revista Saber Digital, 16(02), e20231604. https://doi.org/10.24859/SaberDigital.2023v16n02.1423

Issue

Section

Veterinary Medicine